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Altered sensorium secondary to uremic encephalopathy

 This is an online E-log entry blog to discuss and understand the clinical data analysis of a patient, to develop competency in comprehending clinical problems, and providing evidence- based inputs in order to come up with a diagnosis and effective treatment plan to the best of my ability.


A 70 year old male who is a daily wage labourer by occupation was brought to the casualty ward with the chief complaints of altered sensorium since 3 days and fever, shortness of breath and a productive cough since 23 days

Timeline

23 days ago:The patient was apparently asymptomatic 23 days ago when he went on a sudden alcohol binge for a couple of days following which he developed cough assosciated with sputum (scanty, non foul smelling, non sanguinous) and shortness of breath that could initially be classified under Class 2 NYHA(SOB with ordinary activity, slight limitation of physical activity) but gradually progressed to class 4(SOB at rest, severe limitation of physical activity). He also had burning sensation of the oral cavity that he recalls to have begun around the same time.

Following these complaints, the patient was taken to a nearby Government hospital, where he was trated symptomatically. 

20 days ago: The patient was shifted to another local hospital where a chest X Ray was done and he was told he has viral pneumonia of the right lung. 

3 days ago: The patient was brought to our hospital by his wife who said that she noticed a change in his responsiveness and slurring of speech that began 3 days ago. The patient presented to the casuality ward with some drowsiness, but he was arousable. 

On examination of his oral cavity, multiple erythematous lesions are seen over his hard palate 


PAST HISTORY

No similar complaints in the past.

No H/o DM ,HTN, TB, Asthma, epilepsy, CAD.

No known history of surgeries or blood transfusions.


FAMILY HISTORY

No history of similar illnesses among immediate family members. 

The patient lost his first wife to an unknown illness 30 years ago. He has 2 daughters with his second wife. 

No history of CKD, DM,HTN,CVA, TB, Asthma or CAD among his immediate family members. 


PERSONAL HISTORY

The patient is married.

Diet: Mixed 

Appetite: decreased recently

Sleep:Adequate 

Bowel and bladder: Decreased urine output

No known drug allergies

He consumes 150ml of Alcohol every other day, his last intake was 23 days back.


GENERAL EXAMINATION


Patient is conscious, not coherant or cooperative, not oriented to time, place and person. He appears confused and irritated.

Moderately built and nourished. 

No pallor, icterus, cyanosis, clubbing, lymphadenopathy, edema. 

VITALS:

Temperature: febrile on arrival

PR: 87 bpm

BP: 120/70 mmHg

RR: 24 cpm

SpO2: 98% with 4L of O2

GRBS: 229mg/dl


SYSTEMIC EXAMINATION:

CNS: E4V4M6

Sensory examination: Normal

Motor examination: Normal

Cranial nerve functions: intact

Speech: slurred

Kernig's sign: Positive 

Brudzinski neck and leg signs: Negative 

RS: B/L Crepts +, Dullness to percussion on right upper lobe, NVBS

CVS: S1, S2 heard, no murmurs

P/A: Soft, non tender


Erythematous lesions seen on the hard palate 



Kernig's sign positive: Patient grimaced as the leg was being extended 


Brudzinski sign: Negative 


INVESTIGATIONS:

1) Hemogram (6/1/22)






2) Blood grouping and Rh type




3) APTT

07/01/22



08/01/22



4) Prothrombin time

07/01/22


08/01/22



5) ABG


6) HIV 1/2 Rapid test : Non reactive


7) HBsAg- Rapid 


8) CUE


9) CBP


10) Blood fasting sugar (07/01/22)


11) Blood Urea



12) Serum Creatinine


13) Serum Uric Acid


14) ECG 



06/1/22, 7am


07/1/22, 11:12am and 11:16am


07/1/22, 7:50pm and 8:01pm


16) Covid RT-PCR: NEGATIVE (tested on arrival) 

17) Sputum for AFB: NEGATIVE

18) Abdominal USG



PROVISIONAL DIAGNOSISAltered sensorium as a consequence of exacerbated uremic encephelopathy along with acute kidney injury secondary to sepsis, viral pneumonia of the right upper lobe in a 70 year old



TREATMENT:

1. MUCOPAIN Gel BD* 1 week

2. BETADINE mouth gargles TID* 1 week

3. Tab MVT OD* 15 days

4. Inj PIPTAZ 2.25gm TID

5. THIAMINE in 100ml normal saline TID

6. Tab AZITHROMYCIN 500mg*PO/OD

7. Inj LASIX 40mg IV BD

8. Tab Montek-LC

9. Tab ACEBROPHYLLINE

10. Tab Pulmoclear PO OD

11. Syp: Ambroxyl 15ml PO TID

12. Nebulizer with BUDECORT- 8th hourly

Duolin- 12th hourly

13. Inj HYDROCORTISONE 100mg IV stat

14. Inj VIT K 1 ampoule in 100ml NS for slow IV 

Other measures: Head elevation

Vitals checked every 4hrs

 O2 inhalation to maintain SpO2 greater than 94%

Monitor urinary output

GRBS every 6th hourly

Chest physiotherapy

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